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Download Full Version Halloween 2 The GameEffects of the alkaloid 7-hydroxy-9-methoxyaporphine on epidermal growth factor (EGF) and mitogenic binding sites of EGF and transferrin in the rat kidney.
The alkaloid 7-hydroxy-9-methoxyaporphine (7-HMOP) was found to be toxic for the rat kidney. Epidermal growth factor (EGF) was found in the kidney of adult rats and in proximal tubular cells. Mitogenic binding sites for EGF and transferrin were present in proximal tubular cells. The present studies demonstrate that 7-HMOP at a dose of 1.5 mg/kg iv produced marked proximal tubular necrosis, damage to the outer medullary tubular epithelium, and in untreated animals a slight increase in serum corticosterone and a decrease in serum inorganic phosphate. 7-HMOP produced a 30% decrease in the number of EGF-binding sites in the kidney of the rat. The number of transferrin-binding sites per 100 mg kidney was increased. These effects were not dose dependent, occurred over a wide dose range, and were present at 24 hours after administration of 7-HMOP. The results suggest that 7-HMOP interferes with binding of the growth factor EGF to its receptors and that the resulting alteration of binding alters cellular integrity of proximal tubular cells in the kidney.Cylinder compressors, such as Roots-type or centrifugal compressors, have a cylinder whose bottom has a discharge port orifice (discharge port) and a suction port orifice (suction port) formed in a shaft hole which is provided so as to penetrate the bottom. The upper surface of the bottom is formed into the shape of a concavity having a suction port orifice (suction port orifice) formed in the center. The orifice shapes of the discharge port orifice and the suction port orifice are substantially identical to each other, and the orifice shapes of the discharge port orifice and the suction port
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